Gamma-Irradiated Scrub Typhus Immunogens: Development and Duration of Immunity
نویسندگان
چکیده
منابع مشابه
Gamma-irradiated scrub typhus immunogens: development of cell-mediated immunity after vaccination of inbred mice.
Mice immunized with three injections of gamma-irradiated Karp strain of Rickettsia tsutsugamushi were evaluated for the presence of cell-mediated immunity by using delayed-type hypersensitivity, antigen-induced lymphocyte proliferation, and antigen-induced lymphokine production. These animals also were evaluated for levels of circulating antibody after immunization as well as for the presence o...
متن کاملGamma-irradiated scrub typhus immunogens: analysis for residual, replicating rickettsiae.
Scrub typhus immunogens that received inadequate gamma radiation contained residual, viable rickettsiae. The presence of these organisms in the host was masked by the rapid immune response elicited by the large number of inactivated rickettsiae. Transfer of homogenized spleen cells from immunized mice to normal syngeneic recipients provided a sensitive technique for the detection of these viabl...
متن کاملGamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains.
Scrub typhus immunogens were prepared from Rickettsia tsutsugamushi strains Karp, Kato, Gilliam, Kostival, and Buie by exposing frozen infected yolk sac suspensions to 300 krad of gamma radiation. Mouse protection tests showed that each of the irradiated immunogens protected C3H/HeDub mice against high challenge levels of Karp and Gilliam, but that none of these single-strain immunogens were ca...
متن کاملScrub-typhus.
Scrub typhus is an important emerging tropical infection that can have severe manifestations in children leading to intensive care admission. It is caused by Orientia tsutsugamushi, a gram negative bacterium transmitted to humans by the bite of larval trombiculid mites. The organism is endemic in south-east Asia and the disease is reported from virtually all parts of India. The hallmark of this...
متن کاملDiagnosis of Scrub Typhus
Scrub typhus is transmitted by trombiculid mites and is endemic to East and Southeast Asia and Northern Australia. The clinical syndrome classically consists of a fever, rash, and eschar, but scrub typhus also commonly presents as an undifferentiated fever that requires laboratory confirmation of the diagnosis, usually by indirect fluorescent antibody (IFA) assay. We discuss the limitations of ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1978
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.22.1.80-86.1978